General Information

  • ID:  hor006277
  • Uniprot ID:  Q5CZK5
  • Protein name:  Insulin-like peptide INSL5 A chain
  • Gene name:  INSL5
  • Organism:  Pan troglodytes (Chimpanzee)
  • Family:  Insulin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Pan (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria , Eutheria , Theria , Mammalia (class), Amniota , Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0001664 G protein-coupled receptor binding; GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:2000253 positive regulation of feeding behavior
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QDLQTLCCTDGCSMTDLSALC
  • Length:  21(115-135)
  • Propeptide:  MKGSIFTLFLFSVLLAISEVRSKESVRLCGLEYIRTVIYICASSRWRRHLEGIPQAQQAETGNSFQLPHKREFSEENPAQNLPKVDASGEDRLWGGQMPTEELWKSKKHSVMSRQDLQTLCCTDGCSMTDLSALC
  • Signal peptide:  MKGSIFTLFLFSVLLAISEVRS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  RXFP4
  • Target Unid:  H2Q087
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  45850
  • Structure ID:  AF-Q5CZK5-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006277_AF2.pdbhor006277_ESM.pdb

Physical Information

Mass: 257849 Formula: C86H145N23O35S5
Absent amino acids: EFHIKNPRVWY Common amino acids: CL
pI: 3.34 Basic residues: 0
Polar residues: 10 Hydrophobic residues: 5
Hydrophobicity: 34.76 Boman Index: -2185
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 79.05
Instability Index: 4837.14 Extinction Coefficient cystines: 250
Absorbance 280nm: 12.5

Literature

  • PubMed ID:  16136131
  • Title:  Initial sequence of the chimpanzee genome and comparison with the human genome.
  • PubMed ID:  15707501
  • Title:  Evolution of the relaxin-like peptide family.